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Showing posts with label Disease. Show all posts
Showing posts with label Disease. Show all posts

Thursday, January 3, 2013

In The Battle Against Heart Disease, Stroke, Unhealthy Behaviors Could Slow Progress

Main Category: Obesity / Weight Loss / Fitness
Also Included In: Stroke;  Heart Disease;  Public Health
Article Date: 17 Dec 2012 - 0:00 PST Current ratings for:
In The Battle Against Heart Disease, Stroke, Unhealthy Behaviors Could Slow Progress
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Poor eating and exercise habits could be the game-changer in the fight against heart disease and stroke deaths, according to the American Heart Association's "Heart Disease and Stroke Statistical Update 2013," published in the American Heart Association journal, Circulation.

"Americans need to move a lot more, eat healthier and less, and manage risk factors as soon as they develop," said Alan S. Go, M.D., chairman of the report's writing committee and chief of the Cardiovascular and Metabolic Conditions Section of the Kaiser Permanente Northern California Division of Research in Oakland. "If not, we'll quickly lose the momentum we've gained in reducing heart attack and stroke rates and improving survival over the last few decades."

Between 1999 and 2009, the rate of deaths from cardiovascular disease (CVD) fell 32.7 percent, but still accounted for nearly one in three deaths in the nation. That's 2,150 people dying from CVD each day - about one death every 40 seconds.

In 2010, the American Heart Association set a goal to improve cardiovascular health of all Americans by 20 percent and reduce heart disease and stroke deaths 20 percent by 2020.

However, according to projections in the 2013 report, heart health may only improve by 6 percent if current trends continue. The biggest barriers to success are projected increases in obesity and diabetes, and only modest improvements in diet and physical activity. On a positive note, smoking, high cholesterol and high blood pressure rates are projected to decline.

Among heart disease and stroke risk factors, the most recent data shows: More adults age 20 and over are obese (34.6 percent) than normal or underweight (31.8 percent); 68.2 percent are overweight or obese. Among children ages 2-19, 31.8 percent are overweight or obese. Thirty-two percent of adults report no aerobic activity; 17.7 percent of girls and 10 percent of boys, grades 9-12, report fewer than an hour of aerobic activity in the past week. 13.8 percent of adults have total cholesterol of 240 mg/dL or higher. Thirty-three percent of adults have high blood pressure; African-Americans have among the highest prevalence of high blood pressure (44 percent) worldwide. 8.3 percent of adults have diagnosed diabetes, and 8.2 percent have undiagnosed diabetes; 38.2 percent have prediabetes. Despite four decades of improvement, 21.3 percent of men and 16.7 percent of women age 18 and over still smoke cigarettes; 18.1 percent of students in grades 9-12 report cigarette smoking.

"As the leader in the fight against heart disease and stroke, we are taking a more aggressive and innovative approach, including taking some pages from the playbooks of the public health sector," said Donna Arnett, Ph.D., president of the American Heart Association and chairperson of the Department of Epidemiology at the University of Alabama at Birmingham School of Public Health. "We're focusing on population-based ways to improve health factors for all Americans."

Some of these include: Working with healthcare systems to support and reward providers who help patients improve their health behaviors and manage their health risk factors. Working with insurers to cover preventive health services and reward positive health behaviors and medication adherence. Working with the education community to make changes in schools that support healthy diets and physical activity for children. Building comprehensive worksite wellness programs. Building healthier communities with improved access to healthier foods and green space for physical activity. The association has a wide range of programs and policy initiatives aimed at improving cardiovascular health through risk factor prevention and health care quality, Arnett said. Information on improving your heart health can be found at http://www.MyHeartMyLife.org.

"In this race against time, it will take nationwide efforts driven by communities and systems - a patient-by-patient approach alone won't do it," Arnett said. "But we're optimistic that if we increase our efforts for improvements in prevention and reductions in risk factors, we can be successful - we can save lives."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our obesity / weight loss / fitness section for the latest news on this subject. Additional authors and disclosures are on the manuscript.
American Heart Association Please use one of the following formats to cite this article in your essay, paper or report:

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Tuesday, July 24, 2012

Alzheimer's Disease Process May Be Disrupted By Antioxidant

Main Category: Alzheimer's / Dementia
Also Included In: Cholesterol
Article Date: 12 Apr 2012 - 0:00 PDT Current ratings for:
'Alzheimer's Disease Process May Be Disrupted By Antioxidant'
4 and a half stars5 stars
Alzheimer's disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that reducing iron levels in blood plasma may protect the brain from changes related to AD.

In the current study a group of investigators from led by Dr. Othman Ghribi, PhD, Associate Professor, Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, rabbits were fed a high-cholesterol diet which caused them to accumulate plaques of a small protein called beta-amyloid (Aß). These plaques are toxic to neurons and central to the development of Alzheimer's disease. The rabbits also developed changes in tau protein, which is part of the skeleton of neurons. When this protein becomes heavily phosphorylated, the ability of neurons to conduct electrical signals is disrupted. Following treatment with a drug called deferiprone (an iron chelator), the iron level in the rabbits' blood plasma was reduced and the levels of both beta-amyloid and phosphorylated tau in the brain were returned to normal levels.

Another degenerative process in AD involves the production of reactive oxygen species (ROS) that can damage neurons in the brain. Deferiprone is also thought to suppress this reactive oxygen damage caused by free iron in the bloodstream, however in this study there was no difference in reactive oxygen species in the treated group. It appears that iron in the AD brain is located in the wrong places - in particular it accumulates to very high levels in the cores of beta-amyloid plaques and is very reactive in this setting.

According to Dr. Ghribi, "Our data show that treatment with the iron chelator deferiprone opposes several pathological events induced by a cholesterol-enriched diet...Deferiprone reduced the generation of Aß and lowered levels of tau phosphorylation." While there was no effect on ROS levels, he comments that "It is possible that a higher dose of deferiprone, or combination therapy of deferiprone together with an antioxidant to prevent ROS generation would more-fully protect against the deleterious effects of cholesterol-enriched diet that are relevant to AD pathology."

Noted expert on metals metabolism research on AD Ashley Bush, MD, PhD, Mental Health Research Institute, Melbourne, Australia, adds that "this research highlights the role of metal ions as key modulators for the toxic interactions of risk factors for Alzheimer's disease, in this case cholesterol. Drugs targeting these metal interactions hold promise as disease-modifying agents."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Monday, July 23, 2012

'Good' Cholesterol, May Not Protect Against Heart Disease

Main Category: Heart Disease
Also Included In: Cholesterol
Article Date: 09 May 2012 - 1:00 PDT Current ratings for:
''Good' Cholesterol, May Not Protect Against Heart Disease'
5 stars2 and a half stars
A new study by Harvard School of Public Health (HSPH) researchers has found that a subclass of high-density lipoprotein (HDL) cholesterol, the so-called "good" cholesterol, may not protect against coronary heart disease (CHD) and in fact may be harmful.

This is the first study to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective.

The study was published online in the Journal of the American Heart Association.

"This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavorable HDL with apoC-III," said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study.

A high level of HDL cholesterol is strongly predictive of a low incidence of coronary heart disease (CHD). But trials of drugs that increase HDL cholesterol have not consistently shown decreases in CHD, leading to the hypothesis that HDL cholesterol may contain both protective and non-protective components.

ApoC-III, a proinflammatory protein, resides on the surface of some lipoproteins - both HDL and low-density lipoproteins, or LDL ("bad") cholesterol. The researchers, led by Sacks and Majken Jensen, research associate in the Department of Nutrition at HSPH, examined whether the existence or absence of apoC-III on HDL cholesterol affected the "good" cholesterol's heart-protective qualities, and whether its existence could differentiate HDL cholesterol into two subclasses - those which protect against the risk of future heart disease and those which do not.

Blood samples collected in 1989 and 1990 from 32,826 women in the Brigham and Women's Hospital-based Nurses' Health Study were examined, along with blood samples collected from 1993 to 1995 from 18,225 men in the Health Professionals Follow-up Study. During 10 to 14 years of follow-up, 634 cases of coronary heart disease were documented and matched with controls for age, smoking, and date of blood drawing.

The researchers compared plasma concentrations of total HDL, HDL that has apoC-III, and HDL without apoC-III as predictors of the risk of CHD.

After adjusting for age, smoking status and other dietary and lifestyle cardiovascular risk factors, the researchers found that two different subclasses of HDL have opposite associations with the risk of CHD in apparently healthy men and women. The major HDL type, which lacks apoC-III, had the expected heart-protective association with CHD. But the small fraction (13%) of HDL cholesterol that has apoC-III present on its surface was paradoxically associated with a higher, not lower, risk of future CHD. Those men and women who had HDL apoC-III in the highest 20% of the population had a 60% increased risk of CHD.

The results suggest that measuring HDL apoC-III and HDL without apoC-III rather than the simpler measure of total HDL may be a better gauge of heart disease risk (or of HDL's protective capacity). "Reduction in HDL-apoC-III by diet or drug treatments may become an indicator of efficacy," said Jensen.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our heart disease section for the latest news on this subject. The study was supported by The National Institutes of Health and the Villum Kann Rasmussen Foundation (Denmark).
"Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease," Majken K. Jensen, Eric B. Rimm, Jeremy D. Furtado, Frank M. Sacks, Journal of the American Heart Association, April 2012.
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''Good' Cholesterol, May Not Protect Against Heart Disease'

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Thursday, July 19, 2012

Some Dieting Increases Heart Disease Risk

Main Category: Obesity / Weight Loss / Fitness
Also Included In: Cholesterol;  Heart Disease;  Nutrition / Diet
Article Date: 12 Jun 2012 - 0:00 PDT Current ratings for:
Some Dieting Increases Heart Disease Risk
1 and a half stars5 stars
A 25 year study in Northern Sweden, published in BioMed Central's open access journal Nutrition Journal, is the first to show that a regional and national dietary intervention to reduce fat intake, decreased cholesterol levels, but a switch to the popular low carbohydrate diet was paralleled by an increase in cholesterol levels. Over the entire 25 year period the population BMI continued to increase, regardless of either diet, and both the increase in body mass and increased cholesterol levels are indicators of increased cardiovascular risk.

In the 1970's it was noticed that the incidence of cardiovascular disease was higher in northern Sweden than anywhere else in the country and that for men it was amongst the highest in the world. The Västerbotten Intervention Programme (VIP) was set up in 1985 to address this and was later extended to include the entire country. The VIP included better food labelling, healthy information, cooking demonstrations and health examinations and counselling, including diet advice, and still continues today.

Evaluation of this program was combined with data from the WHO MONICA project which monitors cardiovascular disease risk factors. Researchers from Umeå University, University of Gothenburg, and The National Board of Welfare collaborated to review this information covering a 25 year period from 1986.

The impact of the VIP was clearly seen in the changing intake of fat and carbohydrate. By 1992 the fat intake for men had reduced by 3% for men and 4% for women and remained stable until 2005. Not only did fat intake reduce due to VIP but the types of fat changed, for example from butter to low fat spreads, which was mirrored by a decrease in cholesterol levels. After 2005 the levels of total and saturated fat intake began to increase, returning to levels above those in 1986, and the amount of complex carbohydrates eaten decreased. The timing of this matched the promotion of low GI diets in the media. Consequently cholesterol levels began to once more increase despite the introduction of cholesterol lowering medication.

Prof Ingegerd Johansson, who led this research, commented, "The association between nutrition and health is complex. It involves specific food components, interactions among those food components, and interactions with genetic factors and individual needs. While low carbohydrate/high fat diets may help short term weight loss, these results of this Swedish study demonstrate that long term weight loss is not maintained and that this diet increases blood cholesterol which has a major impact on risk of cardiovascular disease."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our obesity / weight loss / fitness section for the latest news on this subject. Associations among 25-year trends in diet, cholesterol and BMI from 140,000 observations in men and women in Northern Sweden Ingegerd Johansson, Lena Nilsson, Birgitta Stegmayr, Kurt Boman, Göran Hallmans and Anna Winkvist Nutrition Journal (in press)
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Thursday, July 12, 2012

Lean People With Type 2 Diabetes Have Greater Genetic Predisposition To The Disease

Main Category: Diabetes
Also Included In: Genetics
Article Date: 06 Jun 2012 - 0:00 PDT Current ratings for:
'Lean People With Type 2 Diabetes Have Greater Genetic Predisposition To The Disease'
3 and a half starsnot yet rated
Type 2 diabetes is popularly associated with obesity and a sedentary lifestyle. However, just as there are obese people without type 2 diabetes, there are lean people with the disease.

It has long been hypothesised that type 2 diabetes in lean people is more 'genetically driven'. A new study from a research team led by the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, which involved research institutions from around the world, has for the first time proved that lean type 2 diabetes patients have a larger genetic disposition to the disease than their obese counterparts. The study has also identified a new genetic factor associated only with lean diabetes sufferers.

The study is published in PLoS Genetics.

Using genetic data from genome-wide association studies, the research team tested genetic markers across the genome in approximately 5,000 lean patients with type 2 diabetes, 13,000 obese patients with the disease and 75,000 healthy controls.

The team found differences in genetic enrichment between lean and obese cases, which support the hypothesis that lean diabetes sufferers have a greater genetic predisposition to the disease. This is in contrast to obese patients with type 2 diabetes, where factors other than type 2 diabetes genes are more likely to be responsible. In addition, genetic variants near the gene, LAMA1, were linked to type 2 diabetes risk for the first time, with an effect that appeared only in the lean patients.

Dr. John Perry, one of the lead authors of the study, said: "Whenever a new disease gene is found, there is always the potential for it to be used as a drug target for new therapies or as a biomarker, but more work is needed to see whether or not this new gene has that potential."

He added: "This is the first time that a type 2 diabetes gene has been found to act in this way - we do not know why it should be associated in one sub-group of patients and not another. It could point to the fact that type 2 diabetes may not be one disease, but may represent a number of subgroups. Again, more work is required to prove this hypothesis."

Dr. Perry concluded: "This study is a truly international one, bringing together research teams from around the world and leading UK institutions such as the University of Oxford, the University of Cambridge, King's College London, the University of Dundee and the University of Edinburgh."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our diabetes section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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University of Exeter. "Lean People With Type 2 Diabetes Have Greater Genetic Predisposition To The Disease." Medical News Today. MediLexicon, Intl., 6 Jun. 2012. Web.
7 Jun. 2012. APA

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'Lean People With Type 2 Diabetes Have Greater Genetic Predisposition To The Disease'

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Thursday, July 5, 2012

Risk Of Blood-Vessel Constriction Linked To Gum Disease May Be Increased By Specific Protein

Main Category: Dentistry
Also Included In: Cholesterol
Article Date: 20 Apr 2012 - 0:00 PDT Current ratings for:
'Risk Of Blood-Vessel Constriction Linked To Gum Disease May Be Increased By Specific Protein'
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A protein involved in cellular inflammation may increase the risk of plaque containing blood vessels associated with inflammatory gum disease, according to research presented at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology 2012 Scientific Sessions in Chicago.

The protein, CD36, is found in blood cells, as well as many other cell types. Research has shown that CD36 may increase the harmful effects of "bad cholesterol," or low-density lipoprotein (LDL).

Investigators "knocked out," or deleted, the gene responsible for CD36 production, then induced plaque in blood vessels by feeding mice a high fat diet. Some animals were also infected with the bacteria associated with gum disease.

More fatty plaque accumulation occurred in the blood vessels of the animals that were infected with gum disease. In the animals with the deleted CD36 gene, however, vessels remained free of new plaque even when oral inflammation occurred.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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American Heart Association. "Risk Of Blood-Vessel Constriction Linked To Gum Disease May Be Increased By Specific Protein." Medical News Today. MediLexicon, Intl., 20 Apr. 2012. Web.
7 Jun. 2012. APA

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'Risk Of Blood-Vessel Constriction Linked To Gum Disease May Be Increased By Specific Protein'

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